NCT02988102

Role of Concentration of Biomarkers S100B and NSE in Serum in Mild and Moderate Head Trauma

Role of Concentration of Biomarkers S100B and NSE in Serum in Mild and Moderate Head Trauma Injury in Acute Phase in Relation to Head CT and Post Concusion Syndrome.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 70 (estimated)
• Sponsor: University Clinical Centre of Kosova · Academic / Other
• Sex: All
• Age: 1 Year – 65 Years
• Healthy volunteers: Accepted

Summary

In pediatric age groups communication difficulties very sometimes may present further obstacles in obtaining a detailed injury history and early identification of TBI symptoms. Most emergency management protocols are focused exclusively on the identification of the relatively small number of patients who may require operative intervention, as early surgery is believed to improve outcome.

Detailed description

However early rehabilitation can also be effective for the much larger number of patients who do not require surgery\[1\] In addition, Hall and others recently reported that low doses of ionizing radiation to the brain in infancy may influence cognitive abilities in adulthood. \[2\] Accordingly, increased serum concentrations of, for example S100B ( a calcium-binding protein present in high concentrations in glial cells) and neurone-specific enolase ( NSE: a cytoplasmatic enzyme occuring predominantly in neurones ) have been demonstrated to reflect the presence and severity of brain tissue damage in acute head injuries. \[3\] In both pediatric age and adults.

Conditions

• Biomarkers

Interventions

Type	Name	Description
OTHER	Following S100B and NSE in head trauma	Following S100B and NSE in head trauma in correlation with Head CT and post concussion syndrome and Lisat11

Timeline

• Start date: 2016-12-01
• Primary completion: 2016-12-01
• Completion: 2017-08-01
• First posted: 2016-12-09
• Last updated: 2016-12-09

Locations

1 site across 1 country: Albania