NCT02987296

Perioperative Immunonutrition in Colorectal Cancer Patients Undergoing Abdominal Surgery

A Translational Clinical Trial of Perioperative Immunonutrition in Colorectal Cancer Patients Undergoing Abdominal Surgery: PERIOP-02

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Ottawa Hospital Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The immune system plays an important role in helping to kill and prevent cancers. Cells of the immune system, such as natural killer (NK) cells and T cells, do not work as well following surgery. Arginine, an amino acid, is fundamental in metabolic processes of the body. Surgery has shown to cause a reduction of arginine in the body. In turn, this deficiency causes NK cell suppression. In this study, we want to look at the effects of arginine supplementation before and after surgery on NK cell function in surgery patients. In this study, we will be using a nutritional supplement containing arginine and a placebo drink (provided by Enhanced Medical Nutrition) that will be taken by colorectal cancer patients 5 days before surgery and 5 days after surgery. Using patient blood samples, we will measure NK cell levels, arginine levels and also arginase activity.

Conditions

• ColoRectal Cancer

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Immunonutrition with arginine	Nutritional beverage containing supplemental arginine taken 3 times per day
DIETARY_SUPPLEMENT	Immunonutrition without Arginine	Nutritional beverage without supplemental arginine taken 3 times per day

Timeline

• Start date: 2017-03-01
• Primary completion: 2019-06-01
• Completion: 2019-07-01
• First posted: 2016-12-08
• Last updated: 2019-09-06

Locations

1 site across 1 country: Canada