Trials / Unknown
UnknownNCT02985294
Peripheral Physiological Measures as Determinants of Pain Risk
DOLORisk: Understanding Risk Factors and Determinants for Neuropathic Pain - Peripheral Physiological Measures as Determinants of Pain Risk
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- Neuroscience Technologies SLP, Barcelona · Industry
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study evaluates peripheral nervous system function using Multiple Excitability Measures (MEM) to obtain "electrophysiological pain phenotypes"
Detailed description
Using MEM for peripheral sensory and motor axons we want to identify a set of excitability measures that: 1. Correlate with parameters of clinical pain and of pain processing in existing pain patients (cross sectional study), with the aim to obtain an objective Pain Biomarker. 2. Predict development of neuropathic pain in susceptible patients (longitudinal study). Neuropathic Pain Predictor for patients: i. Undergoing surgical procedures associated with a relatively high risk of developing neuropathic pain such as thoracotomy and hernia repair ii. Planning to start chemotherapy with potentially neurotoxic agents such as vincristine
Conditions
- Polyneuropathies
- Peripheral Nerve Injuries
- Peripheral Nervous System Diseases
- Chemotherapy Effects
- Neuralgia
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Multiple Excitability Measures of peripheral nerves | The technique of threshold tracking can be used to obtain several measures of peripheral nerve excitability (Multiple Excitability Measures or MEM), such as refractoriness, supernormality, strength-duration time constant and 'threshold electrotonus' (i.e. the changes in threshold produced by long-lasting depolarizing or hyperpolarizing current pulses). Each of these measurements depends on membrane potential and on other biophysical properties of the axons. Many of these excitability parameters are very constant among different subjects, while other, such as the current/threshold parameters and the super/sub-excitability parameters, appear to be characteristic of an individual |
Timeline
- Start date
- 2016-04-01
- Primary completion
- 2019-03-01
- Completion
- 2020-04-01
- First posted
- 2016-12-07
- Last updated
- 2018-08-23
Locations
1 site across 1 country: Spain
Source: ClinicalTrials.gov record NCT02985294. Inclusion in this directory is not an endorsement.