Trials / Completed
CompletedNCT02983162
Is wGRS Associated With DD Recurrence?
Is the Weighted Genetic Risk Score Associated With Dupuytren Disease Recurrence?
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 427 (actual)
- Sponsor
- University Medical Center Groningen · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence. However, a significant dose-response relation was not found. This might be caused by underestimating the recurrence rate, due to the retrospective nature of determining recurrence. Therefore, we want to do a follow-up measurement of the GODDAF participants, to see whether they suffered from recurrent disease. Objective: We aim to determine whether the wGRS is associated with recurrent DD. Study design: An observational study, in which the participants of the GODDAF study are followed up. Study population: Patients affected by Dupuytren disease, aged 18-96 years, who were previously included in another study on the genetic basis of Dupuytren disease. Intervention (if applicable): NA Main study parameters/endpoints: The main study parameter is the presence of recurrent Dupuytren disease.
Conditions
Timeline
- Start date
- 2017-03-10
- Primary completion
- 2018-08-01
- Completion
- 2018-08-01
- First posted
- 2016-12-06
- Last updated
- 2022-02-10
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT02983162. Inclusion in this directory is not an endorsement.