NCT02977806

Iron Long-Term Labelling Study Malawi

The Evaluation of Iron Metabolism Using a Novel Isotope Dilution Method in Malawian Children, Who Have Previously Participated in a Stable Isotope Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 48 (actual)
• Sponsor: Prof. Michael B. Zimmermann · Academic / Other
• Sex: All
• Age: 3 Years – 10 Years
• Healthy volunteers: Accepted

Summary

Conventional indirect indicators of iron status, using serum and red blood cell biomarkers, are confounded by inflammation from common infections in sub-Saharan Africa, a region with a high prevalence of iron deficiency, making the assessment of iron balance and efficiency of iron intervention difficult. A new method allowing accurate measurement of long-term oral iron absorption and allowing the estimation of iron requirements is highly needed. Such a novel method to quantify iron absorption and requirements using isotope dilution measurements in children should be validated in the present prospective observational study by following-up a group of 49 children given a stable iron isotope in an earlier trial. We will request seven blood samples within 2 years (sampling every four months) from the participants which will allow us to measure isotopic dilution for estimating total oral iron absorption over these 24 months.

Conditions

• Iron Absorption

Timeline

• Start date: 2017-03-27
• Primary completion: 2019-03-15
• Completion: 2019-12-31
• First posted: 2016-11-30
• Last updated: 2019-04-02

Locations

1 site across 1 country: Malawi