NCT02975739

Feasibility of Holmium-166 Micro Brachytherapy in Head and Neck Tumors

Feasibility of Holmium-166 Microspheres for Selective Intra-tumoural Treatment in Head and Neck Cancer: Biodistribution and Safety in Patients With Malignancy of the Tongue

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (actual)
• Sponsor: UMC Utrecht · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main objective is to establish the feasibility of 166-Holmium microspheres for intratumoral injections in oral squamous cell carcinoma (OSCC) of the tongue. Participants will receive intratumoral injections with a low radioactive 166-Holmium microspheres followed by surgical resection

Detailed description

166-Holmium microspheres poly lactic acid microspheres are currently used in selective internal radiation therapy. These microspheres emits beta radiation. The majority of the radiation dose will be absorbed within 3.2 mm with a maximum penetration in tissue of 9 mm. Therefore this can result in a high local tumor ablative dose with minimal dose to healthy adjacent tissue.

Conditions

• Radioisotopes
• Head and Neck Neoplasms

Interventions

Type	Name	Description
DEVICE	Holmium-166 (poly L lactic acid) microspheres	Intratumoral injections of Holmium-166 (poly L lactic acid) microspheres

Timeline

• Start date: 2016-09-01
• Primary completion: 2018-09-05
• Completion: 2018-09-05
• First posted: 2016-11-29
• Last updated: 2018-09-07

Locations

1 site across 1 country: Netherlands