NCT02975505

Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The transition from chronic kidney disease (CKD) to end-stage renal disease ESRD is a vulnerable and challenging period of time for patients and providers. Suboptimal control of blood pressure is known to be common in patients with the advanced stages of CKD, and may contribute to their elevated risk of progression to ESRD, cardiovascular morbidity, and mortality. This proposal is a pilot randomized controlled trial designed to test whether intensive home blood pressure lowering is feasible and safe in patients with advanced CKD as they transition to ESRD.

Detailed description

The transition from advanced chronic kidney disease (CKD), when estimated glomerular filtration rate (eGFR) is \<=30 mL/min/1.73m2, to end-stage renal disease (ESRD) represents a vulnerable period, when multiple physiologic and psychosocial changes occur as patients prepare for either dialysis or kidney transplant. This study is a pilot randomized controlled trial to test the safety and feasibility of studying strict versus usual BP control in a population of patients with advanced CKD (eGFR \<=30 mL/min/1.73m2), including those with diabetes. For this pilot study, we will randomize 120 patients with advanced CKD who have elevated BP to either a home SBP target of \<120 mm Hg (intervention group) versus usual care (130-140 mmHg).

Conditions

• Chronic Kidney Disease
• Bloodpressure
• Hypertension

Interventions

Type	Name	Description
OTHER	Strict blood pressure control	Systolic Blood Pressure Target \< 120 mm Hg (measured at home)

Timeline

• Start date: 2017-02-10
• Primary completion: 2021-07-18
• Completion: 2021-07-18
• First posted: 2016-11-29
• Last updated: 2025-02-17
• Results posted: 2025-02-17

Locations

1 site across 1 country: United States