NCT02975024

Blood Flow Analysis of the Human Mucosa After Vestibuloplasty Procedures

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: Semmelweis University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Apply the LSCI for follow-up the postoperative microcirculation after surgical procedures to enlarge keratinized gingiva in order to characterize the kinetics of the blood flow changes during wound healing in human subjects.

Detailed description

Vestibuloplasty is the common name of those procedures designed to widen the zone of attached gingiva. The apically repositioned split thickness flap with a xenogeneic collagen matrix or with a combination of strip gingival graft and a xenogeneic collagen matrix are frequently used surgical techniques, however no data are available, how these graft tissues affect the microcirculation of the healing gingiva. LSCI is a non-invasive, two dimensional method to evaluate microcirculation of different tissues. This new method let us monitor the entire surgical area real-time during the healing period. The aim of the present study is to define blood flow patterns, which might characterize the wound healing of such surgical procedures during the first 6 months of healing in order to facilitate treatment.

Conditions

• Mucogingival Defect

Interventions

Type	Name	Description
DEVICE	laser speckle contrast imaging of the oral mucosa	Non-invasive method to measure tissue blood perfusion applied for oral mucosa
DEVICE	wound fluid measurement	Wound fluid at the wound margin is collected using filter strip and volumetrically measured by Periotron 8010 instrument.
DEVICE	quantitative determination of VEGF	For the quantitative determination of VEGF in the fourth day wound fluid sample the Human VEGF Quantikine ELISA Kit will be used.

Timeline

• Start date: 2016-11-01
• Primary completion: 2017-12-01
• Completion: 2017-12-01
• First posted: 2016-11-29
• Last updated: 2018-04-18

Locations

1 site across 1 country: Hungary