NCT02968420

Long Term Immune Memory Responses to HPV Vaccination Following 2 vs 3 Doses of Quad-HPV Vaccine

Long Term Immune Memory Responses to Human Papillomavirus (HPV) Vaccination Following 2 Verses 3 Doses of Quadrivalent HPV Vaccine

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: Female
• Age: 17 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The overall aim of this study is to further understand the memory response to HPV vaccination in subjects who have received 2 versus 3 doses of quadrivalent HPV vaccine. Although memory responses can be detected shortly after immunization, the best approach to measure the long-lasting anamnestic response is to challenge with a booster dose years (\> 5) after the original exposure.

Detailed description

This is a single center, interventional study to evaluate long term memory response to Q-HPV vaccination and to natural infection. Memory response will be assessed by measuring seroprotection 8-10 years post Q-HPV vaccination and to challenge with a booster dose years after the original exposure to measure the long-lasting anamnestic response.

Conditions

• Human Papillomavirus

Interventions

Type	Name	Description
BIOLOGICAL	Human Papillomavirus 9-valent Vaccine, Recombinant	All groups will receive a single dose of the Gardasil9 vaccine at Visit 1/Day 0 of the study.

Timeline

• Start date: 2017-09-11
• Primary completion: 2019-05-15
• Completion: 2019-05-15
• First posted: 2016-11-18
• Last updated: 2021-06-25
• Results posted: 2021-06-25

Locations

1 site across 1 country: Canada