Trials / Completed
CompletedNCT02966769
N2 Lung Cancer Project: Neoadjuvant Treatment Followed Surgery Versus Chemoradiation
Multicentric Retrospective Observation Study: Neoadjuvant Treatment and Surgery Versus Definitive Chemoradiation in the Non-Small Cell Lung Cancer (NSCLC) IIIA-N2
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 294 (actual)
- Sponsor
- Grupo de Investigación Clínica en Oncología Radioterapia · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The objective of this multicenter retrospective study is to compare overall survival in patients with stage IIIA-N2 NSCLC treated with neoadjuvant treatment and surgery versus definitive chemoradiation. Secondary objectives are to analyze disease-free survival, median survival, locoregional and distant relapses as well as mortality and toxicity related to treatment.
Detailed description
Based on data published by the Intergroup 0139 trial, induction therapy followed by surgery in patients with stage IIIA-N2 NSCLC can increase overall survival compared to exclusive radical chemoradiation treatment. The major handicap of all studies addressing the role of surgery in IIIA-N2 NSCLC is the difficulty of recruiting patients. Therefore, multicenter studies are necessary to confirm the hypothesis generated by the INT 0139.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Overall survival | Compare overall survival between both groups. |
Timeline
- Start date
- 2016-06-01
- Primary completion
- 2017-03-01
- Completion
- 2017-03-01
- First posted
- 2016-11-17
- Last updated
- 2018-02-19
Locations
1 site across 1 country: Spain
Source: ClinicalTrials.gov record NCT02966769. Inclusion in this directory is not an endorsement.