NCT02966535

The Effect of Prolonged Inspiratory Time on Gas Exchange During Robot-assisted Laparoscopic Surgery With Steep Trendelenburg Position : A Crossover Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: Male
• Age: 20 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Gas exchange disturbance frequently occurs in steep Trendelenburg position during robot-assisted laparoscopic prostatectomy or cystectomy. Due to increased intrathoracic pressure and absorbed carbon dioxide (CO2) gas insufflated into abdominal cavity, hypercapnia as well as hypoxia may occur. Inverse ratio ventilation or prolonged inspiratory time during mechanical ventilation has been reported to be improve gas exchange in adult respiratory distress syndrome. The investigators attempt to test the hypothesis that prolonged inspiratory time may improve the gas exchange during robot-assisted laparoscopic urologic surgery.

Detailed description

Gas exchange disturbance frequently occurs in steep Trendelenburg position during robot-assisted laparoscopic prostatectomy or cystectomy. Due to increased intrathoracic pressure and absorbed CO2 gas insufflated into abdominal cavity, hypercapnia as well as hypoxia may occur. Inverse ratio ventilation or prolonged inspiratory time during mechanical ventilation has been reported to be improve gas exchange in adult respiratory distress syndrome. The investigators attempt to test the hypothesis that prolonged inspiratory time (I:E ratio = 1:1) may improve the gas exchange during robot-assisted laparoscopic urologic surgery.

Conditions

• Prostatic Neoplasm
• Urinary Bladder Neoplasm

Interventions

Type	Name	Description
DEVICE	Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:2 to 1:1)	Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:2 to 1:1)
DEVICE	Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:1 to 1:2)	Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:1 to 1:2)

Timeline

• Start date: 2016-11-01
• Primary completion: 2017-02-01
• Completion: 2017-04-01
• First posted: 2016-11-17
• Last updated: 2019-03-14

Locations

1 site across 1 country: South Korea