Trials / Completed
CompletedNCT02964780
Study on Mechanisms of Changes in Liver Disease and Sex Steroid Metabolism During Weight Loss
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 90 (actual)
- Sponsor
- University Ghent · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The main objective of the study is to gain insight in the early dynamics and mechanisms of recovery of liver disease and sex steroid metabolism during weight loss in obese men and women and to investigate whether surgical weight loss has differential effects as compared to weight loss with life style measures. In addition, we want to evaluate the postprandial hypoglycemic reactive syndrome (PPHRS) in these patients using a standard chewable meal. Secondary objectives are investigating determinants for the changes in sex steroids, liver disease and PPHRS. Possible determinants to be investigated are adipocytokine secretion patterns, body composition, resting metabolism rate, weight loss per se and changes in fat distribution, parameters of fatty acid metabolism, … .
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Gastric bypass surgery | |
| BEHAVIORAL | Conservative weight loss program |
Timeline
- Start date
- 2016-01-19
- Primary completion
- 2020-05-05
- Completion
- 2020-05-05
- First posted
- 2016-11-16
- Last updated
- 2021-12-03
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT02964780. Inclusion in this directory is not an endorsement.