NCT02961829

Multi Interventional Study Exploring HIV-1 Residual Replication: a Step Towards HIV-1 Eradication and Sterilizing Cure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Federal University of São Paulo · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

It is becoming clear that a combination of interventions will be desirable to achieve HIV cure. Therefore the investigators propose a pilot proof of concept study, using combination of a number of different interventions for eradicating residual plasma viremia and decreasing HIV reservoirs. The investigators hypothesize that, (i) antiretroviral intensification using Maraviroc, and/or dolutegravir with (ii) Dendritic Cell vaccination using autologous HIV, and (iii) purging intervention using the Class III HDACs, Sirtuin-1, and (iv) decreasing the ratio of long-lived central memory (TCM)/transitional memory (TTM) CD4+ T-cells using Auranofin will provide a synergistic impact leading to a sterilizing cure of HIV infection. Results of this study may provide insightful evidence for planning the next steps using the more efficacious combination of intervention strategies towards HIV sterilizing cure.

Conditions

• Chronic Infection
• HIV

Interventions

Type	Name	Description
DRUG	Maraviroc	antiretroviral intensification
DRUG	Dolutegravir	antiretroviral intensification
BIOLOGICAL	Dendritic Cell Vaccine	Therapeutic vaccination
DRUG	Auranofin	purging
DRUG	Sirtuin Histone deacetylase inhibitor	latency disruption

Timeline

• Start date: 2015-07-01
• Primary completion: 2019-03-01
• Completion: 2020-03-01
• First posted: 2016-11-11
• Last updated: 2020-07-28

Locations

1 site across 1 country: Brazil