NCT02958215

Phenylephrine and Hypotension During Spinal Anesthesia for Cesarean Section

A Study Evaluating Hypotension and Autonomic Nervous System Dysfunction During Spinal Anesthesia for Cesarean Section and Its Relation to the Effect of Prophylaxis Phenylephrine

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 980 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Pregnant women with a positive preoperative Supine stress test were found to be a subgroup at increased risk of symptomatic hypotension after spinal anesthesia

Detailed description

Patients will be placed in dorsal decubitus dislocating the uterus to the left for a few minutes, with blood pressure and heart rate recorded three times, with a three-minute interval between measurements to obtain mean baseline levels and this will be repeated in an upright position to record the same measurement.Orthostatic hypotension (Orthostatic hypotension "OH" is defined specifically as a 20mmHg drop in systolic, and/or a 10mmHg drop in diastolic blood pressure within 3 minutes of standing.

Conditions

• Anesthesia, Obstetrical
• Anesthesia, Spinal

Interventions

Type	Name	Description
DRUG	Phenylephrine	it will be given as a prophylaxis for prevention of hypotension after spinal anesthesia in pregnant patients undergoing cesarean section
OTHER	Placebo	5 ml normal saline will be given before spinal anesthesia

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-05-01
• Completion: 2017-05-01
• First posted: 2016-11-08
• Last updated: 2017-05-18

Locations

1 site across 1 country: Egypt