NCT02951442

Identification of Markers (Klotho-FGF23 Axis) as Determinant in the Evolution of Arterial Stiffness During the First Year of Renal Transplant

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 117 (actual)
• Sponsor: Hopital Foch · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The primary objective is to show that the contribution of Klotho by the renal graft is an independent determinant of the evolution of the recipient's central arterial stiffness during the first year of renal transplant. The contribution of Klotho by the graft will be estimated by: its circulating concentrations assay, its urinary excretion assay, and, indirectly, by the circulating concentrations of FGF23. The recipient's central arterial stiffness will be estimated by the measure of the carotid-femoral pulse wave velocity, noninvasive reference method for measuring aortic stiffness in human.

Conditions

• Renal Transplant

Interventions

Type	Name	Description
BIOLOGICAL	Biological sample
PROCEDURE	Non invasive Arterial investigations
PROCEDURE	Abdominal tomodensitometry

Timeline

• Start date: 2011-01-01
• Primary completion: 2014-01-28
• Completion: 2014-01-28
• First posted: 2016-11-01
• Last updated: 2018-02-22

Locations

2 sites across 1 country: France