NCT02951013

Transfusion Strategies for Pediatric Liver Transplantation

The Perioperative Liberal or Restrictive Transfusion in Pediatric Liver Transplantation: A Prospective Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 488 (estimated)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 36 Months
• Healthy volunteers: Not accepted

Summary

The patients assigned to the restrictive group will receive transfusion once the hemoglobin concentration falls below 6.0 g per deciliter, with a target hemoglobin range of 7.5 to 8.0 g per deciliter. Patients assigned to the liberal group will receive transfusion once the hemoglobin concentration falls below 8.0 g per deciliter, with a target hemoglobin range of 9.0 to 10.0 g per deciliter. The primary outcome: Survival rate in six months after randomization. Secondary outcomes: Incidence of perioperative complications, including sepsis , pulmonary complications, portal vein thrombosis, hepatic artery thrombosis and transfusion-related adverse events. Intraoperative blood loss, intraoperative blood transfusion amount, postoperative blood transfusion amount in 7 days after surgery, postoperative inflammatory reaction, mechanical ventilation time in the intensive care unit, lengths of stay in the intensive care unit and the hospital，and hospitalization expenses.

Conditions

• Pediatric Patients Who Need Liver Transplantation

Interventions

Type	Name	Description
OTHER	restrictive transfusion	Transfusion will start when the hemoglobin concentration falls below 6.0 g/dL
OTHER	liberal transfusion

Timeline

• Start date: 2016-12-07
• Primary completion: 2022-06-30
• Completion: 2022-12-30
• First posted: 2016-11-01
• Last updated: 2021-10-14

Locations

1 site across 1 country: China