NCT02949076

Skeletal Muscle Atrophy and Dysfunction in Human Cancer

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: University of Vermont · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Cancer and its treatment can have profound effects on skeletal muscle, the most well-recognized being atrophy, weakness and diminished oxidative capacity. These adaptations negatively impact quality of life, treatment decisions and survival. Despite these consequences, the factors promoting these adaptations remain poorly defined and understudied in human patients. To address this gap in knowledge, our goal in this study is to examine the role of muscle disuse as a regulator of muscle size and function in human cancer patients

Conditions

• Nonsmall Cell Lung Cancer

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	Unilateral lower limb resistance exercise will be performed 3 times per week for 8 weeks in non-small cell lung cancer patients on only one leg, while the contralateral leg serves as a non-exercising control.

Timeline

• Start date: 2016-07-01
• Primary completion: 2023-06-01
• Completion: 2023-06-01
• First posted: 2016-10-31
• Last updated: 2023-12-05

Locations

1 site across 1 country: United States