NCT02944097

Bioavailability of Resveratrol From Vineatrol30 Extract Incorporated Into Micelles

Study of the Oral Bioavailability of Trans-epsilon-viniferin and Trans-resveratrol From Native and Micellar Solubilized vineatrol30 Vine Extract

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Hohenheim · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

To enhance the oral bioavailability of the antioxidants trans-resveratrol and trans-ε-viniferin from Vineatrol30 grapevine-shoot extract, the native powder was incorporated into micelles. A single dose, single blind, two arms crossover trial was conducted. Plasma and urine samples were collected at intervals up to 24 h after oral intake of native or micellar Vineatrol30 (500 mg), and resveratrol content was quantified and compared between formulations. Tolerability of the dose was also controlled by safety parameters in plasma.

Conditions

• Safety After Oral Intake
• Pharmacokinetics After Oral Intake

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vineatrol 30 native powder
DIETARY_SUPPLEMENT	Vineatrol 30 micelles

Timeline

• Start date: 2015-03-01
• Primary completion: 2015-05-01
• Completion: 2017-02-01
• First posted: 2016-10-25
• Last updated: 2017-05-03

Locations

1 site across 1 country: Germany