NCT02944084

Absorption and Excretion Kinetics of the Bioactive Ingredients of Rice Bran Extract

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Hohenheim · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The oral absorption and urinary excretion kinetics of the bioactive ingredients from rice bran (gamma-oryzanol, tocotrienols, tocopherols and ferulic acid esters) after incorporation into an oat porridge (oat porridge) compared to unprocessed rice bran extract oil were investigated. The influence of the type of preparation (with water vs. milk) of porridge on the bioavailability of the bioactive compounds was compared. The study followed a single dose (2 g rice bran extract), randomized, three armed crossover study design with ≥1-week washout periods. Plasma and urine samples were collected at intervals up to 24 h after intake.

Conditions

• Safety After Oral Intake
• Pharmacokinetics After Oral Intake

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Rice bran extract
DIETARY_SUPPLEMENT	Porridge in water
DIETARY_SUPPLEMENT	Porridge in milk

Timeline

• Start date: 2016-04-01
• Primary completion: 2016-06-01
• Completion: 2017-04-01
• First posted: 2016-10-25
• Last updated: 2017-05-03

Locations

1 site across 1 country: Germany