NCT02942342

Evaluation of Asymptomatic Coronary Atherosclerotic Disease Among People of Kalamazoo, MI

Evaluation of Asymptomatic Coronary Atherosclerotic Disease Among People of Kalamazoo County and Neighboring Areas in Michigan, Who Have Risk Factors of Coronary Artery Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 240 (estimated)
• Sponsor: Borgess Research Institute · Academic / Other
• Sex: All
• Age: 35 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The primary goal of this study is to determine the prevalence of undiagnosed asymptomatic coronary artery disease (CAD) in Kalamazoo and its neighboring areas using Coronary Computed Tomography (CCTA) and Coronary Artery Calcium Score (CACS) to assess if asymptomatic CAD is widespread enough to warrant implementation of CCTA as a routine screening tool. Additionally, this study will use the CCTA results to evaluate several methods of assessing CAD risk in the asymptomatic population including Framingham Risk Score (FRS) and Reynold's Risk Score, Biomarkers (High sensitivity C-Reactive Protein, Fibrinogen, Vertical Auto Profile, oxidized Low Density Lipoprotein (LDL), Apolipoprotein A1 (ApoA1), Apolipoprotein B1 (ApoB1), Vitamin D, Homocysteine) as well as a large panel of genetic markers of atherosclerosis and dyslipidemia.

Conditions

• Coronary Artery Disease
• Atherosclerosis

Interventions

Type	Name	Description
PROCEDURE	Computed Tomography (CT) Scan	CT Scans will be used as a diagnostic tool for asymptomatic CAD.

Timeline

• Start date: 2016-03-01
• Primary completion: 2022-01-01
• Completion: 2022-03-01
• First posted: 2016-10-24
• Last updated: 2020-09-01

Locations

1 site across 1 country: United States