Trials / Unknown
UnknownNCT02940184
GLP-1 Signaling in Truncally Vagotomized Subjects
Vagal Mechanisms Mediating the Effects of Glucagon-Like Peptide 1 (GLP-1) on the Endocrine Pancreas - the Entero-endocrine Axis.
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- Sponsor
- University of Copenhagen · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Investigation of the importance of vagal signaling for the glucohomeostatic effects of GLP-1. The study will include physiological studies of truncally vagotomized participants and matched controls.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Tablet Sitagliptin 100mg (evening before and morning of experiments) | On one of two experiment days participants will have Dipeptidyl peptidase 4 activity inhibited using a DPP-4 inhibitor (Sitagliptin). |
| OTHER | Intestinal Fructose administration | On both experimental days fructose (35g dissolved in water, total volume 100mL) will be administered via an intrajejunal tube |
Timeline
- Start date
- 2016-06-01
- Primary completion
- 2018-10-01
- Completion
- 2018-10-01
- First posted
- 2016-10-20
- Last updated
- 2018-05-22
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT02940184. Inclusion in this directory is not an endorsement.