NCT02940171

Timing of Surgery And Outcome in Burn Patients ( EARLYBURN )

Impact of Timing of Surgery on Outcome of Severely Ill Burn Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 470 (actual)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The prognostic of burn patients has improved over the last decades. Early excision of full thickness burns is thought to be one of the key factors which have led to prognostic improvement. Best timing for burn excision remain uncertain, however. In this multicenter observational study, we aim at exploring the impact of timing of surgery on outcome in severely ill burn patients using a propensity analysis.

Detailed description

The first aim of the study is to explore the impact of timing of the first surgery on outcome of severely ill burn patients. Because a randomization would not be feasible in this setting, we will use a propensity analysis in matching patients receiving early surgery and those receiving late surgery. Secondary aims are to evaluate the impact of the timing of surgery on morbidity (organs failure, infections, sepsis) but also to assess the diagnostic and prognostic value of plasma and urine biomarkers in severely ill burn patients

Conditions

• Burns

Interventions

Type	Name	Description
PROCEDURE	Early Excision of full thickness burn	first excision surgery of full -thickness burn performed within 48 hours from burn injury
PROCEDURE	Late Excision of full thickness burn	first excision surgery of full -thickness burn performed after 48 hours from burn injury

Timeline

• Start date: 2016-12-25
• Primary completion: 2023-12-11
• Completion: 2023-12-11
• First posted: 2016-10-20
• Last updated: 2024-07-10

Locations

1 site across 1 country: France