NCT02940106

Clinical Pregnancies After Cryopreservation of Donor Oocytes With an Open or Closed Device

Investigation of the Clinical Pregnancies Obtained After Cryopreservation of Donor Oocytes With an Open or Closed Device

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: Female
• Age: 18 Years – 47 Years
• Healthy volunteers: Accepted

Summary

This randomized pilot study will assess if there is a difference in clinical pregnancies using donor oocytes cryopreserved in either a closed or a semi-closed vitrification device.

Detailed description

Oocyte cryopreservation was optimized by the use of a new technique: vitrification. Vitrification can be performed using either open devices (where the oocytes are in direct contact with the liquid nitrogen) or closed systems (where the oocytes are never in contact with liquid nitrogen). Previous studies have associated the use of open devices to higher oocyte survival rates and better embryo development. However, any beneficial effect on clinical pregnancy rates is yet to be proven. Hence, the objective of this study is to compare the clinical pregnancy rates of open and closed oocyte vitrification devices.

Conditions

• Infertility

Interventions

Type	Name	Description
DEVICE	Cryotop device	a different device for oocyte vitrification (with a very high cooling rate)
DEVICE	CBSvit device	a different device for oocyte vitrification (with a lower cooling rate)

Timeline

• Start date: 2016-10-01
• Primary completion: 2018-07-01
• Completion: 2018-07-01
• First posted: 2016-10-20
• Last updated: 2022-01-26

Locations

1 site across 1 country: Belgium