NCT02939703

Integrating Quantitative Energetics Determines the Microbiome's Contribution to Energy Balance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

We propose to study the role of the gut microbiome in the development of obesity, and whether we can change the microbiome's contribution to host energy balance through diet. We have created a novel model that explicitly links the effects of microorganisms on human energy balance and modeled weight change, and will use the power of metabolic ward studies to measure small changes in energy absorption, total daily energy expenditure, and/or food intake that affect long-term weight gain or loss. By integrating clinical measurements, bioreactor experiments, and mathematical modeling, we will be able to describe cause-and-effect mechanisms that will enable a quantification of the microbiota's contribution to weight gain and inspire future studies on the interactions of diet, the gut microbiome, and human physiology.

Conditions

• Obesity

Interventions

Type	Name	Description
OTHER	Diet	Participants will consume either a Control Western Diet or a Microbiome Enhancer Diet.

Timeline

• Start date: 2017-06-14
• Primary completion: 2019-07-20
• Completion: 2019-07-23
• First posted: 2016-10-20
• Last updated: 2021-06-30

Locations

1 site across 1 country: United States