NCT02935244

Advanced Understanding of Staphylococcus Aureus Infections in Europe - Surgical Site Infections

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5,004 (actual)
• Sponsor: UMC Utrecht · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

ASPIRE-SSI is a prospective, observational, multicentre cohort study among adult surgical patients, which aims to determine the incidence of healthcare-associated S. aureus infections, particularly S. aureus surgical site infections (SSIs), across Europe and to assess the most important risk factors for this type of infection.

Detailed description

The primary objective of ASPIRE-SSI is to determine the incidence of S. aureus infections, particularly S. aureus SSIs, in various adult surgical patient populations, and to identify the patient-related, pathogen-related, and contextual risk factors for the development of S. aureus SSI. Using this information, a SSI prediction tool will be derived for future clinical trials and public health interventions aimed at SSI prevention. Furthermore, immunologic features protective against S. aureus SSI will also be assessed. The knowledge obtained by this study will enable identification of the surgical patients most at risk of developing S. aureus infections, particularly S. aureus SSI, and who would probably benefit most from new interventions given prophylactically and specifically to prevent S. aureus infections.

Conditions

• Staphylococcus Aureus
• Surgical Wound Infection

Timeline

• Start date: 2016-12-01
• Primary completion: 2019-11-01
• Completion: 2020-01-01
• First posted: 2016-10-17
• Last updated: 2021-05-03

Locations

33 sites across 10 countries: Belgium, Czechia, Estonia, France, Italy, Netherlands, Romania, Serbia, Spain, United Kingdom