NCT02935010

Tailored Versus Empiric Therapy for Helicobacter Pylori Treatment

Efficacy of Antibiotic Susceptibility-based Tailored Versus Empiric Therapy for Helicobacter Pylori First-line Treatment：a Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 382 (actual)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

With markedly increased antibiotic resistance and unsatisfactory efficacies of common empiric eradication regimens in the mainland of China, tailored therapy may be the best choice to achieve good efficacy. This study compared the eradication rates, safety, and compliance of antibiotic sensitivity-based tailored therapy compared with empiric bismuth quadruple therapy in the naive patients with Helicobacter pylori infection.

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	Esomeprazole	proton pump inhibitor
DRUG	Bismuth Potassium Citrate	Gastric mucosal protective drug with anti-H. pylori effect
DRUG	Amoxicillin	antibiotic for H. pylori eradication
DRUG	Clarithromycin	antibiotic for H. pylori eradication
DRUG	Metronidazole	antibiotic for H. pylori eradication
DRUG	Levofloxacin	antibiotic for H. pylori eradication

Timeline

• Start date: 2017-02-05
• Primary completion: 2018-03-31
• Completion: 2018-03-31
• First posted: 2016-10-17
• Last updated: 2018-08-15

Locations

5 sites across 1 country: China