Trials / Unknown
UnknownNCT02932501
Medication-related Osteonecrosis of the Jaw (MRONJ) Registry
International, Multicenter, Prospective Registry to Collect Data of Treatment Patterns of Patients With Medication-related Osteonecrosis of the Jaw (MRONJ) and Their Outcome
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 518 (actual)
- Sponsor
- AO Clinical Investigation and Publishing Documentation · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Approximately 500 patients will be included in this patient registry. Data collection includes demographics, clinical data of underlying disease and use of bisphosphonates, denosumab and antiangiogenic drugs , degree and extension of osteonecrosis, osteonecrosis-specific treatment, outcomes and complications within 1 year after treatment.
Detailed description
Approximately 500 patients diagnosed with medication-related osteonecrosis of the jaw will be enrolled in the study. Patients will undergo standard (routine) of care treatment, either conservative or surgical or both, and followed up during one year after the initiation of the treatment. Treatment outcome (development of the condition), pain and complications will be collected and documented over the duration of the registry.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Conservative treatment | Disinfectant mouth rinses, Antibiotic therapy, Antifungal therapy |
| PROCEDURE | Surgical treatment | Superficial debridement, Complete removal of necrotic bone, Complete bone resection, When applicable revision and soft tissue coverage |
| PROCEDURE | Adjuvant non-surgical treatment | Hyperbaric oxygen therapy Pentoxifylline and tocopherol Ozone therapy Low level laser therapy Pain relief Anti-inflammatory treatment Platelet rich plasma Parathyroid hormone and teriparatide Bone morphogenetic protein |
Timeline
- Start date
- 2017-08-14
- Primary completion
- 2023-10-13
- Completion
- 2024-04-01
- First posted
- 2016-10-13
- Last updated
- 2024-03-20
Locations
14 sites across 10 countries: United States, Finland, Germany, Netherlands, Qatar, Romania, Slovenia, South Korea, Spain, Switzerland
Source: ClinicalTrials.gov record NCT02932501. Inclusion in this directory is not an endorsement.