NCT02930330

Interval Training in Cardiac Rehabilitation

Interval Training in Cardiac Rehabilitation: Effects on Cardiorespiratory Fitness and Platelet Function - A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: Male
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether high intensity interval training (INT) is more effective in suppressing platelet reactivity than continuous, moderate intensity training (CONT) in patients undergoing cardiac rehabilitation after percutaneous coronary intervention.

Detailed description

Background: Platelets play an important role in cardiovascular disease: First, they promote the development of atherosclerotic lesions, and second, platelets form vessel occluding thrombi on top of (ruptured) lesions, ultimately leading to thrombotic events like myocardial infarctions (MCI). Whereas acute, strenuous exercise causes platelet activation and transiently increases the risk for MCIs, long-term chronic exercise training results in a clear reduction of both platelet activation and MCI incidence. Exercise training plays a key role in cardiac rehabilitation, since improvements in cardiorespiratory fitness (CRF) are associated with decreased mortality in these patients. With respect to CRF improvements, high-intensity interval training has been demonstrated to be more effective than moderate-intensity continuous exercise. However, the beneficial effect of high-intensity interval training on platelet function in patients with cardiovascular disease has never been investigated. Scientific question: The aim of this study is to determine the effect of interval training in cardiac rehabilitation on platelet function. Hypotheses: Cardiac rehabilitation with interval training components (INT) reduces 1. platelet activation and platelet reactivity at physical rest 2. changes of platelet activation and -reactivity induced by acute, strenuous exercise to a greater extent than cardiac rehabilitation consisting exclusively of moderate-intensity continuous exercise training (CONT). Work program: 80 patients at the beginning of phase II cardiac rehabilitation will be randomly assigned to an interval group or to a control group. In both groups, patients will exercise 4x / week for 12 weeks. At the beginning, after 6 weeks and at the end an exercise test will be carried out. Blood will be taken before (platelet function at rest) and immediately after each exercise test (platelet function after acute, strenuous exercise). Basal platelet activation as well as platelet responsiveness towards a platelet agonist (platelet reactivity) will be analyzed.

Conditions

• Atherosclerosis
• Coronary Artery Disease

Interventions

Type	Name	Description
BEHAVIORAL	INT	* 5 min warm-up (40% Pmax\*) * 30 min high intensity interval training (1 min 100% Pmax, 1 min 20% Pmax, in alternating sequence) * 10 min cool-down (30% Pmax) Pmax\*: Maximal power output (Watt) achieved at the end of an incremental exercise test.
BEHAVIORAL	CONT	* 5 min warm-up (40% Pmax\*) * 30 min moderate intensity continuous training (60% Pmax) * 10 min cool-down (30% Pmax) Pmax\*: Maximal power output (Watt) achieved at the end of an incremental exercise test.

Timeline

• Start date: 2015-10-01
• Primary completion: 2017-06-14
• Completion: 2017-06-14
• First posted: 2016-10-12
• Last updated: 2017-08-31

Locations

1 site across 1 country: Austria