NCT02929927

Estimate the Effect of aPDT on Root Canal Disinfection

Acess the Clinical Effect of Antimicrobial Photodynamic Therapy (aPDT) on Root Canal Disinfection

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Fujian Medical University · Academic / Other
• Sex: All
• Age: 12 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to compare the clinical effect of traditional root canal disinfection and aPDT on root canal disinfection. And provide the reference for clinical application and experience.

Detailed description

The study of groups: Group1: Calcium hydroxide-based antibacterial dressing - two session root canal treatment Group2: aPDT - one session root canal treatment Microbiological measurement. Filled with sterile PBS, the root canals were sampled immediately before and after the disinfection procedures.

Conditions

• Root Canal Disinfection

Interventions

Type	Name	Description
PROCEDURE	Rubber dam isolation	tooth was isolated using a rubber dam in order to avoid the outside microbe
DEVICE	aPDT	Inject the photosensitizer (PS)to the parallel orifice of the canal,use the small file to stir the PS for 60 s,then irradiation 120 s.
DRUG	1% iodine tincture	use 1% iodine tincture to disinfect the crown of the teeth.in order to avoid the outside microbe
DRUG	2.5%NaClO	use 2.5% NaClO as irrigants
PROCEDURE	root canal preparation	mechanical preparation with NITIMTWO to 25#06, and cleaned with 5 ml of 2.5% NaClO between each endodontic file. At the end of the procedure, root canals were ultrasonic irrigated with 2.5% NaClO, 17% EDTA for 1 min followed by irrigation with 0.9% normal saline to remove the smear layer
PROCEDURE	root canal obturation	filled the canals with AH-Plus sealer and Gutta-percha by vertical condensation

Timeline

• Start date: 2016-03-01
• Primary completion: 2023-12-01
• Completion: 2024-12-01
• First posted: 2016-10-11
• Last updated: 2022-11-17

Locations

1 site across 1 country: China