NCT02929901

The Effects of Coffee Main Constituents (Caffeine and Chlorogenic Acid) Supplementation on Inflammatory, Metabolic Factors, Hepatic Steatosis and Fibrosis in None- Alcoholic Fatty Liver Patients With Type 2 Diabetes

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: National Nutrition and Food Technology Institute · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the effects of coffee main constituents (caffeine and chlorogenic acid) supplements on inflammatory, metabolic factors, hepatic steatosis and fibrosis in none- alcoholic fatty liver patients with type 2 diabetes. Two hundred patients with fatty liver and type 2 diabetes will be randomly assigned to one of four groups: group 1, caffeine (200 mg/d) plus chlorogenic acid (200 mg/d); group 2, caffeine (200 mg/d) plus placebo; group 3, chlorogenic acid (200 mg/d) plus placebo; group 4, placebo plus placebo. Supplementation will be daily and will supervise for 6 months.

Conditions

• Type 2 Diabetes Nonalcoholic Fatty Liver

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	caffeine and chlorogenic acid	caffeine plus chlorogenic acid
DIETARY_SUPPLEMENT	caffeine	caffeine plus placebo
DIETARY_SUPPLEMENT	chlorogenic acid	chlorogenic acid plus placebo
DIETARY_SUPPLEMENT	placebo	placebo plus placebo

Timeline

• Start date: 2016-12-01
• Primary completion: 2018-09-01
• Completion: 2019-03-01
• First posted: 2016-10-11
• Last updated: 2019-05-01

Locations

1 site across 1 country: Iran