NCT02929459

Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut Microbiota

Effects of Oral Riboflavin Supplementation on the Growth of Faecalibacterium Prausnitzii and the Impact on the Gut Microbiota: A Randomized, Double-blind, Placebo-controlled Human Intervention Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 105 (estimated)
• Sponsor: dsm-firmenich Switzerland AG · Industry
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this trial is to investigate comprehensively the effect of riboflavin supplementation on the abundance of F. prausnitzii and on other members of the gut microbiota in faeces of healthy volunteers. Additionally it will be assessed whether riboflavin supplementation affects the abundance of potentially pathogenic bacteria such as adherent invasive E. coli (AIEC). Finally, the effect of riboflavin supplementation on the production of Short Chain Fatty Acids, the release of gut hormones and potential changes in glucose homeostasis and appetite perception will be assessed.

Conditions

• Gut Microbiota

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Riboflavin Dose 1
DIETARY_SUPPLEMENT	Riboflavin Dose 2
OTHER	Placebo

Timeline

• Start date: 2016-11-01
• Primary completion: 2018-10-01
• Completion: 2019-12-01
• First posted: 2016-10-11
• Last updated: 2020-01-22

Locations

1 site across 1 country: Netherlands