NCT02928939

Therapeutic Conflicts and Multimorbidity

Therapeutic Conflicts in Hospitalized Patients: Retrospective Analyses of Patients With GI Bleeding or Exacerbated Diabetes and Impact of Multimorbidity.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,101 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or chronic diseases. Guidance should be available for frequent encountered situations, e.g. gastrointestinal bleeding or exacerbation of diabetes mellitus.

Detailed description

The study investigates multimorbidity in view of the occurrence of two different therapeutic conflicts or dilemma situations, respectively. The first concerns patients with diagnosis of gastrointestinal bleeding and prescription of anticoagulants or/and antiplatelet drugs (e.g., warfarin, clopidogrel and acetylsalicylic acid) as a risk factor for bleeding events. The second concerns patients with diagnosis of exacerbated diabetes mellitus and prescription of corticosteroids as a risk factor for worsening of blood glucose.

Conditions

• Gastrointestinal Hemorrhage
• Diabetes Complications
• Multimorbidity

Interventions

Type	Name	Description
OTHER	drug-drug or drug-disease interaction

Timeline

• Start date: 2016-10-01
• Primary completion: 2020-08-01
• Completion: 2021-04-01
• First posted: 2016-10-10
• Last updated: 2021-04-08

Locations

1 site across 1 country: Switzerland