NCT02925858

Effect of Ketamine on Analgesia Post-Cardiac Surgery

Pilot Study: The Effect of Intraoperative Ketamine on Analgesia Post-Cardiac Surgery and Prevention of Chronic Pain

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Jewish General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized, controlled, double-blind pilot study evaluating the effect of an intraoperative infusion of intravenous Ketamine on the quantity of opioid consumed postoperatively in coronary artery bypass surgery patients receiving a median sternotomy.

Detailed description

This is a randomized, controlled, double-blind pilot study to determine the effectiveness of intraoperative Ketamine administration on pain after coronary artery bypass surgery. Patients will be randomized to receive ketamine or saline prior to incision, with a continuous infusion throughout surgery. Opioid dose administered in the first 48 hours will then be documented as the primary outcome

Conditions

• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	Normal Saline Flush, 0.9% Injectable Solution_#1	Normal saline infusion mimicking infusion rate of ketamine for a given weight
DRUG	Ketamine Hydrochloride	Ketamine IV infusion (0.5mg/kg bolus prior to incision, 0.5mg/kg/hr until the end of surgery)

Timeline

• Start date: 2017-08-28
• Primary completion: 2018-11-01
• Completion: 2018-11-27
• First posted: 2016-10-06
• Last updated: 2019-09-06
• Results posted: 2019-09-06

Locations

1 site across 1 country: Canada