NCT02925130

Beta2-mimetic and Central Nervous System

Beta2-mimetic and Central Nervous System: Effects of Salbutamol on Cortical Excitability and Cerebral Activation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Beta2-mimetics such as Salbutamol have been shown to have ergogenic effects. Acute and chronic inhaled or oral doses of Salbutamol have been shown to increase whole body exercise and muscle performances. The underlying mechanisms are however unclear. Some data suggest that Salbutamol may have some effects on the central nervous system which may explain the improved exercise and neuromuscular performances. The present study aims to assess the effects of acite inhaled or oral Salbutamol intake on the neuromuscular system by using neurostimulation techniques and magnetic resonance imaging.

Detailed description

The effects of Salbutamol intake will be assessed by using transcranial magnetic stimulation on one hand and magnetic resonance imaging on the other hand. Maximal voluntary activation and cerebral activation will be measured during motor tasks performed until exhaustion after acute inhaled slabutamol intake, acture oral salbutamol intake or oral placebo intake.

Conditions

• Adrenergic Beta-2 Agonist Effect
• Albuterol Effect

Interventions

Type	Name	Description
DRUG	Salbutamol	Acute intake of Albuterol, a beta2-mimetic, either inhaled or oral.
DRUG	Placebo	Acute oral intake of a placebo drug

Timeline

• Start date: 2016-10-01
• Primary completion: 2017-09-28
• Completion: 2017-09-28
• First posted: 2016-10-05
• Last updated: 2017-10-02

Locations

1 site across 1 country: France