NCT02924896

Effect of Palm Olein Intake on Lipid Profile and Appetite Regulation

The Chemical Structure of a Lipid Determines Its Effect on Blood Lipid Profile and Appetite Regulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Aims: To investigate whether acute ingestions of palm oil will have an effect on appetite regulation

Detailed description

Design: A randomized, single blind, cross over design including 4 single study visits separated by a week. Visit 1 is an acclimatization visit followed by visit 2,3, and 4 where different types of fat will be given. Population: 12 healthy males and females aged between 18 and 60 years with body mass index (BMI) between 18.5- 29.9kg/m2 and normal fasting plasma glucose and no evidence of insulin resistance will be recruited. No-pre existing morbidity including cardiac, hepatic or renal disease, history of diabetes, hypertension or hyperlipidaemia. Treatment: Acclimatization visit: At visit 1, all participants will be given a milkshake like drink containing fat, protein and carbohydrate. A cannula will be inserted for the duration of the study day but no blood will be taken. Studies show than during the first visit stress response can affect the metabolic response to the study drink resulting in inaccurate results. Study visit 2,3,4: following the acclimatization visit, participants will attend 3 more study visits separated by a week to test the metabolic response to the following fats: palm olein, interesterified palm olein and soybean oil in random order. Participants will be asked to complete a visual analogue scale questionnaire about their appetite at each time point. Fasting and postprandial plasma glucose, insulin, appetite hormones and lipids will be measured.

Conditions

• Lipidaemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Palm olein	60g of palm olein will be given in a milkshake at breakfast
DIETARY_SUPPLEMENT	Interesterified palm olein	60g of interesterified palm olein will be given in a milkshake at breakfast
DIETARY_SUPPLEMENT	Soybean oil	60g of soybean oil will be given in a milkshake at breakfast

Timeline

• Start date: 2016-09-01
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2016-10-05
• Last updated: 2025-06-22
• Results posted: 2025-06-22

Locations

1 site across 1 country: United Kingdom