NCT02921282

Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 26 (actual)
• Sponsor: Centre for Addiction and Mental Health · Academic / Other
• Sex: All
• Age: 19 Years – 64 Years
• Healthy volunteers: Accepted

Summary

In this study, potential associations between several genetic polymorphisms and nicotine dependence will be examined. The relative reinforcing efficacy of cigarettes using the forced-choice procedure will be assessed. In addition, reactivity to smoking cues using a reliable procedure will be conducted.

Detailed description

It is known that cannabinoid and dopamine receptors can be important modulators of response to nicotine and its associated cues. In this study participants will be genotyped to determine whether there is a relationship between CB1 or D3 genes and the reinforcing properties of nicotine or the subjective effects of nicotine-associated cues. In one session, participants will chose between two different cigarettes, each with different properties. In another session, physiological responses and craving will be measured when presented with cues that remind participants of nicotine. At some point during the study, blood will be collected for genotyping and this will processed to study whether CB1 or D3 genotype influences these responses to nicotine or cues.

Conditions

• Cigarette Smoking Behavior

Interventions

Type	Name	Description
GENETIC	Genotype dopamine	Laboratory investigations of nicotine reinforcement
GENETIC	Genotype cannabinoids	Laboratory investigations of nicotine reinforcement

Timeline

• Start date: 2016-08-01
• Primary completion: 2019-11-29
• Completion: 2019-11-29
• First posted: 2016-10-03
• Last updated: 2024-03-08

Locations

1 site across 1 country: Canada