NCT02920515

Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty

Multi-site Study of Comprehensive Treatment for Children Precocious Puberty

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 740 (actual)
• Sponsor: Ruijin Hospital · Academic / Other
• Sex: Female
• Age: 2 Years – 14 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, multicentric, comparative, non-randomized interventional study in which subjects diagnosed with central precocious puberty (CPP) and early puberty (EP) were treated for 6 months to compare the effect with GnRHa and traditional Chinese medicines.

Detailed description

740 girls with CPP and EP participated in this study, all participates were divided into GnRHa group, traditional chinese medicines group and blank group. After at least six months therapy with GnRHa or traditional Chinese medicines, the investigators compare clinical parameters, sex hormone, bone age and ovarian ultrasound in three groups.

Conditions

• Central Precocious Puberty

Interventions

Type	Name	Description
DRUG	Triptorlin or Leuprorelin	Gonadotrophin releasing hormone agonists (GnRHa)
DRUG	Zhibo dihuang pills	Traditional Chinese Medicine
DRUG	Dabu ying pills	Traditional Chinese Medicine

Timeline

• Start date: 2012-09-01
• Primary completion: 2015-08-01
• Completion: 2015-08-01
• First posted: 2016-09-30
• Last updated: 2016-09-30