NCT02916355

Role of Interleukin (IL)-1 in Postprandial Fatigue - The Chäschüechli 2 Study

Role of IL-1 in Postprandial Fatigue - The Chäschüechli 2 Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: Male
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Role of IL-1 in postprandial fatigue - The Chäschüechli 2 Study It is a randomized, single dose, placebo-controlled, double blind, cross-over, proof-of-concept study. 16 healthy young men will be included in this study. The objective of this study is to evaluate if severity of postprandial fatigue is driven by IL-1. Since fatigue is associated with increased cytokine levels, and since fatigue in chronic inflammatory settings, such as type 2 diabetes, can be reduced by inhibition of IL-1β, postprandial fatigue might also respond to anti-inflammatory intervention with IL-1 inhibition. The aim of the study is to investigate whether postprandial fatigue is, at least in part, driven by the IL-1 system.

Conditions

• Adiposity

Interventions

Type	Name	Description
DRUG	Anakinra	Subjects will receive Anakinra infusion and afterwards they will be fed a very fat containing meal, and postprandial fatigue will be measured regularly until 3,5 hour after the meal.
DRUG	NaCl	subjects will receive NaCl infusion and afterwards they will be fed a very fat containing meal, and postprandial fatigue will be measured regularly until 3,5 hour after the meal.

Timeline

• Start date: 2016-08-01
• Primary completion: 2017-04-01
• Completion: 2017-04-03
• First posted: 2016-09-27
• Last updated: 2018-01-29

Locations

1 site across 1 country: Switzerland