NCT02916121

Potential Intervention Strategy With Folic Acid and Vitamin B12 in Patients With Schizophrenia

Relationships of One-carbon Cycle Pathway With Psychopathology and Metabolic Abnormalities in Patients With Schizophrenia and Potential Intervention Strategy With Folic Acid and Vitamin B12

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 88 (estimated)
• Sponsor: Taipei Medical University WanFang Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators study aims are: 1. To investigate folate, vitamin B12, and homocysteine levels in patients with schizophrenia. 2. To evaluate the relationships among folate, vitamin B12, and homocysteine levels, genetic variants of one-carbon cycle pathway, psychopathology, including positive symptoms, negative symptoms, and cognition, and metabolic abnormalities in patients with schizophrenia. 3. For patients with low folate levels, the investigators would like to conduct a 24-week double-blinded, placebo-controlled of folic acid (5 mg/d) and vitamin B12 (500 ug/d) supplementation study to know whether combination of folic acid and vitamin B12 can improve patients' psychopathology or metabolic profiles, and the effects of genetic variants in one-carbon cycle pathway on treatment response.

Conditions

• Schizophrenia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	folic acid 5 mg/cap	the intervention includes folic acid 5 mg/d and vitamin B12 500 ug/d
OTHER	Placebo	placebo

Timeline

• Start date: 2016-10-01
• Primary completion: 2018-08-01
• Completion: 2018-12-01
• First posted: 2016-09-27
• Last updated: 2016-09-27

Locations

1 site across 1 country: Taiwan