NCT02915614

Effects of Pulmonary Rehabilitation on Skeletal Muscle in COPD Patients

Effects of Pulmonary Rehabilitation on Skeletal Muscle Morphology and Metabolism in PiMM vs. PiZZ COPD Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Schön Klinik Berchtesgadener Land · Academic / Other
• Sex: All
• Age: 25 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

In a former study, the investigator observed significant differences in the response to pulmonary rehabilitation between COPD patients with the "normal" genetic variant of alpha-1 antitrypsin (PiMM) and those with a homozygous deficient variant (PiZZ) (Jarosch et al., 2016, DOI: 10.1159/000449509). PiZZ COPD patients showed less improvement in exercise capacity compared to PiMM patients. This latter finding was mirrored by an increase of oxidative myofiber type I proportion - that is important for aerobic exercises in daily life - in PiMM but not PiZZ patients. Based on this finding of impaired skeletal muscle adaptation, the aim of this study is to compare the effects of pulmonary rehabilitation including exercise training on a) specific enzymes of energy metabolism reflecting the oxidative capacity of the skeletal muscle and b) the analogue gene expression of these oxidative enzymes in a cohort of PiMM and PiZZ COPD patients.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
PROCEDURE	Pulmonary rehabilitation	3-weeks of inpatient pulmonary Rehabilitation including exercise Training (daily endurance and strength Training)

Timeline

• Start date: 2017-03-02
• Primary completion: 2023-12-01
• Completion: 2024-01-01
• First posted: 2016-09-27
• Last updated: 2022-11-30

Locations

1 site across 1 country: Germany