NCT02912299

Investigation on Differences in Skin Sodium Content Between Normal Subjects and ICU-patients

Onderzoek Naar Intracutane Natriumopslag Bij Intensive Care patiënten (InCa-studie)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Frisius Medisch Centrum · Academic / Other
• Sex: All
• Age: 45 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the differens in sodium storage in skin between normal subjects, patients after cardiac surgery and septic patients.

Detailed description

According to the current paradigm ICU-acquired hypernatremia is mainly an iatrogenic problem, caused by sodium overload or water deficit. In spite of several interventions to reduce sodium intake and optimize fluid balance, critically ill patients still develop hypernatremia. These patients also seem to have an inability to excrete sodium, hence develop a positive sodium balance. In animals sodium storage in the third compartment was found. Our hypothesis is that sodium storage in the third compartment is different in critically ill patients and this difference could play a role in the development of ICU-acquired hypernatremia.

Conditions

• Hypernatremia

Interventions

Type	Name	Description
PROCEDURE	Skin biopsies	2 3mm skin biopsies will be taken
OTHER	Blood and urine analysis	Measurement of sodium, potassium and kidneyfunction in blood and urine.
OTHER	Blood collection for RNA-investigation	A blood sample that, in case of relevant differences between groups, could be used for RNA-profiling.

Timeline

• Start date: 2016-11-03
• Primary completion: 2017-09-05
• Completion: 2017-09-05
• First posted: 2016-09-23
• Last updated: 2017-09-08

Locations

1 site across 1 country: Netherlands