Trials / Completed
CompletedNCT02909283
Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration
Determinants of Cerebral Oxygenation and Perfusion in SCA Children Based on Combined ASL MRI, NIRS and Hemorheological Investigation
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 64 (actual)
- Sponsor
- Imagine Institute · Academic / Other
- Sex
- All
- Age
- 6 Years – 16 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling (ASL) perfusion MR (Magnetic Resonnance) imaging, brain Near Infra-Red Spectroscopy (NIRS) and red blood cell (RBC) rheological properties.
Detailed description
The investigators hypothesize that brain perfusion and/or oxygenation modifications may be evidenced in SCA children who have no microarteriopathy and may correlate with hemorheological abnormalities and impaired vasomotion. A multimodal approach designed to study a. cerebral perfusion and oxygenation, b. flow motion properties and c. blood rheological parameters might help to describe the different processes involved in cerebral ischemia.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Physical exams and blood analyzes | Blood samples collection (for DNA, plasma and cells analyzes) ; Hemorheologic analyzes ; ASL sequence on MRI ; Near Infra Red Spectroscopy (NIRS) and associated cardiofrequency analyze. |
Timeline
- Start date
- 2015-03-02
- Primary completion
- 2017-07-11
- Completion
- 2017-07-11
- First posted
- 2016-09-21
- Last updated
- 2018-11-14
Locations
2 sites across 1 country: France
Source: ClinicalTrials.gov record NCT02909283. Inclusion in this directory is not an endorsement.