NCT02906137

Gut-Associated Lymphocyte Trafficking

Altered Homing of T Lymphocytes to the Gut and Poor Immune Reconstitution of the Intestinal Mucosa in Treated HIV-infected Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: ANRS, Emerging Infectious Diseases · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The gut immune barrier is not fully restored in HIV-1-infected subjects despite they were receiving antiretroviral treatment. This leaky gut leads to microbial translocation from the gut lumen into the bloodstream that fuels deleterious systemic inflammation. The chemotaxis axes that allow T lymphocytes to migrate from the blood to the gut mucosa in order to reconstitute the mucosal immune barrier seems altered in treated HIV-1-infected subjects.This study aims at better understanding the mechanisms involved in this lack of mucosal immune restoration.

Detailed description

Pathophysiological study in human subjects, comparative, national, multicentric and prospective. Peripheral blood and intestinal biopsies will be collected.

Conditions

• HIV-1 Infection

Interventions

Type	Name	Description
OTHER	Peripheral blood and intestinal biopsies will be collected	Blood draw and intestinal biopsies

Timeline

• Start date: 2017-02-06
• Primary completion: 2020-02-25
• Completion: 2020-02-25
• First posted: 2016-09-19
• Last updated: 2022-01-14

Locations

2 sites across 1 country: France