NCT02903199

Whey Protein Effect on Glycaemic and Appetite Responses in T2D

The Effect of Pre-meal Whey Protein on Glycaemic and Appetite Responses in Type II Diabetic Males

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Northumbria University · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The current study will investigate the effect if whey protein on postprandial glycaemia and appetite in type II diabetics, assessing incretin (GLP-1, GIP), insulin, and appetite control (leptin, PYY3-36) hormone responses.

Detailed description

Whey protein accounts of \~20% of whole milk protein. Ingestion of whey protein at meal times generates insulinotrophic/β-cell stimulation via amino acid absorption and the bioactive peptides generated during gastrointestinal digestion, resulting in attenuation of postprandial blood glucose. The bioactive peptides stimulate the release of incretin hormone, GLP-1, and inhibit DPP-IV activity potentially decreasing the rate of GLP-1 degradation. The current study will employ a randomised, double-blind, counter-balanced, cross-over design, whereby participants will each complete three trials; a) whey protein, b) hydrolysed protein, and c) placebo intervention. Hydrolysed protein provides amino acid content, without bioactive peptides associated with incretin release, therefore, demonstrating insulinotrophic properties, only. Many studies within the literature are limited for practical reasons, such as investigating high dosages (30-50 g) of whey protein, or high glycaemic index meal types which would be unlikely to form part of habitual dietary activity of type II diabetics. Therefore, the current study will objectively measure postprandial glycaemic and appetite responses following the ingestion of whey/hydrolysed protein, whilst ensuring ecological validity, dosages (18 g) and test meals applicable to everyday life, and true clinical utility for managing type-II diabetes by integrating interventions into the habitual lives of type-II diabetic individuals.

Conditions

• Type II Diabetes Mellitus
• Glucose Metabolism Disorders
• Metabolic Diseases

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Whey Protein	Whey protein (18 g) administered immediately prior to breakfast and lunch meals.
DIETARY_SUPPLEMENT	Hydrolysed Protein	Hydrolysed whey protein (19.1 g) administered immediately prior to breakfast and lunch meals.
DIETARY_SUPPLEMENT	Placebo	Placebo intervention administered immediately prior to breakfast and lunch meals.

Timeline

• Start date: 2015-07-01
• Primary completion: 2016-02-01
• Completion: 2016-10-01
• First posted: 2016-09-16
• Last updated: 2016-09-16

Locations

1 site across 1 country: United Kingdom