NCT02903017

Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage

Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage: A Double-Blind, Randomized, Placebo-Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 114 (actual)
• Sponsor: Kocaeli University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Upper gastrointestinal hemorrhage is a frequently diagnosis in emergency departments. Although new drugs and endoscopic techniques were easily applied in various settings in this condition, the role of local administered therapies such as antifibrinolytic agents remain unclear. The investigators aimed to compare standard therapy (proton pump inhibitors, endoscopic treatments etc.) and standard therapy + local administered tranexamic acid in upper gastrointestinal hemorrhage in a double-blind, randomized trial.

Conditions

• Gastrointestinal Hemorrhage
• Tranexamic Acid
• Emergency Department
• Antifibrinolytic Agents

Interventions

Type	Name	Description
DRUG	Tranexamic acid 5%	Via nasogastric tube, 100 mL
DRUG	Placebo	Via nasogastric tube, 100 mL

Timeline

• Start date: 2016-09-01
• Primary completion: 2018-03-01
• Completion: 2018-03-01
• First posted: 2016-09-16
• Last updated: 2018-03-06

Locations

1 site across 1 country: Turkey (Türkiye)