NCT02902614

Side of Embryo Biopsy Interfering Implantation Potential

Effect of Embryo Biopsy Side on Post Biopsy Blastocyst Structurs and Implantation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Ahmad Mustafa Mohamed Metwalley · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Selection of side of embryo biopsy that will not interfering with implantation power of developed blastocyst embryo during biopsy procedure arranged for PGT.

Detailed description

During process of embryo biopsy, it was indicated to avoid contacting cells closer to inner cell mass as it can decrease the quality of embryo and its structural composition. However, recommendation for collection from the trophectoderm (TE) side is indicated. Absence of differentiation during cleavage-stage or morula stage at day 3 and day 4 respectively, will present the needful to focus a specific location for embryo biopsy during pre-blastocyst stages for embryo going to do genetic testing before implantation or embryo transfer. In articulation around the second polar body or the animal pole of embryo, collection of the cell from the vegetal pole in crospondence to avoide collection form the animal pole is to be compare the results of implantation for biopsy done using the animal pole side or the random non organized biosy procedure.

Conditions

• Preimplantation Diagnosis

Interventions

Type	Name	Description
PROCEDURE	Vegetal Pole blastomer embryo	for day 3 embryo biopsy / cleavage stage
PROCEDURE	Animal Pole blastomer embryo	for day 3 embryo biopsy / cleavage stage

Timeline

• Start date: 2015-01-01
• Primary completion: 2018-12-01
• Completion: 2018-12-02
• First posted: 2016-09-16
• Last updated: 2019-01-15

Locations

2 sites across 2 countries: Bahrain, Egypt