Trials / Active Not Recruiting
Active Not RecruitingNCT02900833
Impact of Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy
Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 440 (estimated)
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild · Network
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance. The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.
Conditions
Timeline
- Start date
- 2016-03-24
- Primary completion
- 2022-12-12
- Completion
- 2026-08-31
- First posted
- 2016-09-14
- Last updated
- 2026-01-20
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02900833. Inclusion in this directory is not an endorsement.