NCT02900430

Invasives Aspergillosis in Acute Myeloid Leukemia

The Incidence of Invasive Aspergillosis in Acute Myeloid Leukemia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 246 (actual)
• Sponsor: University Hospital, Brest · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with acute myeloid leukemia (AML) are at risk to develop severe infections whose invasive aspergillosis (IA). These infections are leading to an important morbidity and mortality. Antifungal prophylaxis is recommended by posaconazole for AML patients during neutropenia induced by induction chemotherapy. Their application is not uniform.

Detailed description

Invasive aspergillosis are frequent infections in hematological malignancy in particular during neutropenia induced by chemotherapy. Their incidence ranged between 5 to 25% according to the literature. Mortality may reach 30%. Our study described IA incidence in AML patients treated by intensive chemotherapy depending on antifungal prophylaxis by posaconazole. From 2009 to 2011, any patients received antifungal prophylaxis. From 2012 to 2015, patients received posaconazole during induction and salvage chemotherapy. During the all study period, efficacy of posaconazole is evaluated according to construction/demolition periods in hospital. All patients are hospitalized in High Efficiency Particulate Air (HEPA) filtration system.

Conditions

• Acute Myeloid Leukemia
• Invasive Aspergillosis

Interventions

Type	Name	Description
OTHER	Patients without antifungal prophylaxis	Epidemiology data: clinical and biological informations collecting
DRUG	Patients with antifungal prophylaxis	Hospitalized patients between 2012 and 2015 received Posaconazole prophylaxis during neutropenia period induced by induction or salvage chemotherapy.

Timeline

• Start date: 2009-01-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2016-09-14
• Last updated: 2016-09-14

Locations

1 site across 1 country: France