NCT02895646

Genomic Study of Genetic Polymorphisms Involved in Immediate Allergic Reactions to Beta-lactam Antibiotics

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 2,356 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Beta-lactam antibiotics include penicillin and cephalosporins and are among the most prescribed antibiotics. This category of drugs is the most involved in immediate allergic manifestations with 2% reactions in treated subjects and a fatal outcome in 1/50000 treatments. Reactions are IgE-mediated and have a considerable but unknown genetic origin, revealed by studies in groups of different ethnical origins in the same geographical region. There are also some families with a high frequency of allergic reactions without identified Mendelian inheritance. The purpose of this study is to identify predictive risk factors associated to immediate allergic reactions against beta-lactam antibiotics with a pangenomic approach. A secondary purpose is to identify rare predictive factors with homozygosity mapping and exome sequencing in various families with high risk of allergy to beta-lactam antibiotics.

Conditions

• Beta-Lactams Allergy
• Hypersensitivity

Interventions

Type	Name	Description
OTHER	Collection of blood sample

Timeline

• Start date: 2012-06-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2016-09-12
• Last updated: 2017-02-03