NCT02895633

Osteoarticular Tumor Characterization by Advanced Imaging

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,090 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which association of methods could improve non invasive tissue characterization. Secondary purposes are: * to determine a possible correlation between some parameters and the histological grade (FNCLCC) * to suggest a coherent diagnostic imaging approach for osteoarticular tumors. The ancillary study will enroll patients needing radiological tumor follow-up. The purpose is to identify tools for evaluation of tumor activity and therapeutic response before modification of morpho-volumetric data.

Detailed description

Patients refered for the initial evaluation of suspected osteoarticular masses will be included in this study after signing an informed consent. Histologic analysis will be used as a gold standard. The following imaging techniques will be evaluated: * contrast enhanced ultrasonography * Low dose CT perfusion * Magnetic resonance perfusion * Diffusion weighted imaging * Magnetic resonance proton spectroscopy

Conditions

• Bone Tumor
• Soft Tissue Tumor

Interventions

Type	Name	Description
OTHER	Ecography	Standard Doppler ultrasound and perfusion imaging after injection of Sonovue
OTHER	CT scan	With injection of Iomeron 400
OTHER	MRI	With injection of gadolinium (Multihance)

Timeline

• Start date: 2009-11-01
• Primary completion: 2018-11-01
• Completion: 2020-11-01
• First posted: 2016-09-12
• Last updated: 2016-09-12

Locations

1 site across 1 country: France